General Information

  • ID:  hor002387
  • Uniprot ID:  Q9PRP6
  • Protein name:  Motilin
  • Gene name:  MLN
  • Organism:  Gallus gallus (Chicken)
  • Family:  Motilin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gallus (genus), Phasianinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006939 smooth muscle contraction; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FVPFFTQSDIQKMQEKERNKGQ
  • Length:  22
  • Propeptide:  FVPFFTQSDIQKMQEKERNKGQ
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle which is age-dependent reduction
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  MLNR
  • Target Unid:  B2KSC0
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9PRP6-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q9PRP6-F1.pdbhor002387_AF2.pdbhor002387_ESM.pdb

Physical Information

Mass: 306078 Formula: C119H185N33O36S
Absent amino acids: ACHLWY Common amino acids: Q
pI: 9.44 Basic residues: 4
Polar residues: 4 Hydrophobic residues: 5
Hydrophobicity: -130.45 Boman Index: -6749
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 30.91
Instability Index: 7625.91 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8801522
  • Title:  Isolation, Sequence, and Bioactivity of Chicken Motilin.
  • PubMed ID:  23454175
  • Title:   Age-dependent Reduction of Ghrelin- And Motilin-Induced Contractile Activity in the Chicken Gastrointestinal Tract